A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome | Science Translational Medicine

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vol. 4 no. 124 124ra29

DOI:

https://doi.org/10.1126/scitranslmed.3003771

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American Association for the Advancement of Science

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Received for publication January 26, 2012
Accepted for publication February 10, 2012
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Copyright © 2012, American Association for the Advancement of Science

Author Information

Yichen Shi¹,
Peter Kirwan¹,
James Smith¹,
Glenn MacLean²,
Stuart H. Orkin² and
Frederick J. Livesey¹,*

¹Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
²Howard Hughes Medical Institute, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children’s Hospital Boston and Harvard Stem Cell Institute, Boston, MA 02115, USA.

↵*To whom correspondence should be addressed. E-mail: rick{at}gurdon.cam.ac.uk

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Science Translational Medicine: 4 (124)

Science Translational Medicine

Vol 4, Issue 124
07 March 2012

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A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome

By Yichen Shi, Peter Kirwan, James Smith, Glenn MacLean, Stuart H. Orkin, Frederick J. Livesey

Science Translational Medicine07 Mar 2012 : 124ra29

Cultured cerebral cortex neurons generated from human Down syndrome induced pluripotent stem cells rapidly develop Alzheimer’s disease pathologies.

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A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome

By Yichen Shi, Peter Kirwan, James Smith, Glenn MacLean, Stuart H. Orkin, Frederick J. Livesey

Science Translational Medicine07 Mar 2012 : 124ra29

Cultured cerebral cortex neurons generated from human Down syndrome induced pluripotent stem cells rapidly develop Alzheimer’s disease pathologies.

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