07 March 2012
Vol 4, Issue 124

About The Cover

Cover image expansion

ONLINE COVER The Heads and Tails of It. According to Greek mythology, the Chimera was a fire-breathing creature made of parts from different animals: the body and maned head of a lioness, a head of a goat, and a snake's head at the end of the tail. Leventhal et al. used a mixture of enriched mobilized cells to create chimeras of a different sort in kidney transplant patients. Five of eight recipients of nonrelated donor mismatched kidneys with this therapy had durable mixed hematopoietic chimerism and were weaned off of immunosuppressive therapies by 1 year after transplantation, with no signs that the donor cells were attacking the graft recipient. This approach could free some patients from the difficulties associated with lifelong immunosuppression. [CREDIT: Gianni Dagli Oti/CORBIS]