Contents
Vol 4, Issue 124
Contents
Focus
- The Quest for Transplantation Tolerance: Have We Finally Sipped from the Cup?
New advances in achieving hematopoietic chimerism may facilitate immunological tolerance to kidney transplants.
Perspective
- Impersonalized Medicine
Fasting simultaneously enhances normal cell function and potentiates the effects of conventional chemotherapeutic agents on tumor growth, metastasis, and long-term survival.
Research Articles
- Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy
Short-term starvation increases the effectiveness of chemotherapy against a wide range of tumor cell types.
- Chimerism and Tolerance Without GVHD or Engraftment Syndrome in HLA-Mismatched Combined Kidney and Hematopoietic Stem Cell Transplantation
Durable chimerism and donor-specific tolerance can be safely achieved without GVHD in HLA-mismatched donor/recipient pairs.
- A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome
Cultured cerebral cortex neurons generated from human Down syndrome induced pluripotent stem cells rapidly develop Alzheimer’s disease pathologies.
Editors' Choice
- Stent Today, Gone Tomorrow
A new polymer-coated, drug-eluting stent is able to keep arteries open and blood flowing in patients.
- Antiretroviral Therapy as Prevention in South Africa
Modeling shows that South Africa’s new HIV treatment guidelines could prevent almost 20% of new HIV infections cost-effectively.
- Staying Alive: Specifically Targeting Tumor Vessels with Anti-Angiogenesis Therapy
Targeting the endothelial marker TEM8 delays tumor growth without harming healthy blood vessels.
- Patients Point the Way
A bedside-to-bench approach identified a novel therapeutic target in sepsis—one that may be manipulated by an established class of drugs.
- Giving Statins a Run for Their Money?
A serotonin receptor antagonist suppresses atherosclerosis caused by a high-cholesterol diet in a rabbit model.
