29 February 2012
Vol 4, Issue 123
  • Contents

    • Perspectives

      • Toward a Meningitis-Free World

        A conjugate vaccine against the A, C, W, and Y, serogroups of meningococcus and a protein-based vaccine against serogroup B should bring to an end the scourge of meninogococcal meningitis.

    • Research Articles

    • Editors' Choice

      • Self-Destructive But Self-Controlled

        T helper 17 cells are sparse at sites of inflammation because their orphan receptor checks proliferation of these autoimmune-related agents.

      • Some Disassembly Required

        siRNA-loaded nanoparticles can be taken apart in and cleared by the kidneys, leaving room for optimization of these charged delivery vehicles.

      • Joule Thief?

        The scaffold protein tamalin plays a critical role in the neuroplasticity triggered by electroconvulsive shock.

      • Who Is in the House?

        Endothelial and perivascular cells provide stem cell factor in hematopoietic stem cellbone marrow niches.

      • Rx: An Anti-Obesity Probiotic

        A plant-derived bacterium decreases body weight gain and fatty liver in obese mice fed a high-fat diet.

    • Podcast

About The Cover

Cover image expansion

ONLINE COVER Go with the Flow. In healthy people, blood flows uninterrupted throughout the body. In patients with sickle cell disease, however, red blood cells take on a crescent shape that physically impedes the flow of blood. Wood et al. have created a microfluidic device that can measure such decreased flow velocity in blood samples from sickle cell patients. This biophysical indicator can then be used to stratify patients on the basis of disease severity and predict response to therapy. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]