Research ArticleBreast Cancer

Breast Cancer–Associated Abraxas Mutation Disrupts Nuclear Localization and DNA Damage Response Functions

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Science Translational Medicine  22 Feb 2012:
Vol. 4, Issue 122, pp. 122ra23
DOI: 10.1126/scitranslmed.3003223

Article Information

vol. 4 no. 122 122ra23

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History: 
  • Received for publication September 15, 2011
  • Accepted for publication January 16, 2012
  • .

Author Information

  1. Szilvia Solyom1,*,,
  2. Bernadette Aressy2,*,
  3. Katri Pylkäs1,*,
  4. Jeffrey Patterson-Fortin2,3,*,
  5. Jaana M. Hartikainen4,5,
  6. Anne Kallioniemi6,
  7. Saila Kauppila7,
  8. Jenni Nikkilä1,
  9. Veli-Matti Kosma4,5,
  10. Arto Mannermaa4,5,
  11. Roger A. Greenberg2,8, and
  12. Robert Winqvist1,
  1. 1Laboratory of Cancer Genetics, Department of Clinical Genetics, Institute of Clinical Medicine and Biocenter Oulu, University of Oulu, Oulu University Hospital, Aapistie 5A, FI-90220 Oulu, Finland.
  2. 2Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104–6160, USA.
  3. 3University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104–6160, USA.
  4. 4School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland.
  5. 5Department of Clinical Pathology, Kuopio University Hospital, Biocenter Kuopio, Cancer Center of Eastern Finland, FI-70211 Kuopio, Finland.
  6. 6Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, FI-33014 Tampere, Finland.
  7. 7Department of Pathology, University of Oulu, Oulu University Hospital, P.O. Box 5000, FI-90014 University of Oulu, Oulu, Finland.
  8. 8Department of Pathology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104–6160, USA.
  1. To whom correspondence should be addressed. E-mail: robert.winqvist{at}oulu.fi (R.W.); rogergr{at}mail.med.upenn.edu (R.A.G.)
  • * These authors contributed equally to this work.

  • Present address: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Broadway Research Building, 733 North Broadway, Baltimore, MD 21205, USA.

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