Contents
Vol 4, Issue 122
Contents
Editorial
- Reengineering Device Translation Timelines
Innovative engineering will substantially shorten the translational medicine timeline from concept to clinical application of medical devices.
Commentary
- Recalibrating Intellectual Property Rights to Enhance Translational Research Collaborations
New collaborative models of therapeutic research and development require active governance of intellectual property rights to enable sharing.
Research Articles
- First-in-Human Testing of a Wirelessly Controlled Drug Delivery Microchip
Implanted in humans, a wirelessly controlled, microchip-based drug delivery device demonstrates pharmacokinetic profiles of an anti-osteoporosis drug that are similar to subcutaneous injections.
- MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion
miR-21 modulates abdominal aortic aneurysm development by regulating cell proliferation and apoptosis within the aortic wall.
- Breast Cancer–Associated Abraxas Mutation Disrupts Nuclear Localization and DNA Damage Response Functions
A germline mutation in the Abraxas gene impairs BRCA1 DNA damage response function and is associated with familial breast cancer.
Editors' Choice
- A Cut Deeper in the Lung and Colorectal Cancer Genome
New gene fusions in lung and colorectal cancers may be able to be targeted with multikinase inhibitors already in clinical use.
- Higher Consciousness
The psychedelic drug psilocybin uncouples the activity of key brain areas, providing insight into new therapies for psychiatric disorders.
- “Red Rover, Red Rover, Send Insulin Right Over!”
Nanoparticles containing a metal ion chelator increase the absorption of orally delivered insulin into the bloodstream.
- IgM Antibodies to the Rescue!
One of our body’s natural defenses might help prevent organ transplant rejection.
