Research ArticleParkinson’s Disease

Phosphorylated α-Synuclein in Parkinson’s Disease

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Science Translational Medicine  15 Feb 2012:
Vol. 4, Issue 121, pp. 121ra20
DOI: 10.1126/scitranslmed.3002566

Article Information

vol. 4 no. 121 121ra20

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication April 25, 2011
  • Accepted for publication January 27, 2012
  • .

Author Information

  1. Yu Wang1,2,*,
  2. Min Shi1,*,
  3. Kathryn A. Chung3,
  4. Cyrus P. Zabetian4,5,
  5. James B. Leverenz5,6,7,
  6. Daniela Berg8,9,
  7. Karin Srulijes8,9,
  8. John Q. Trojanowski10,
  9. Virginia M.-Y. Lee10,
  10. Andrew D. Siderowf11,
  11. Howard Hurtig11,
  12. Irene Litvan12,
  13. Mya C. Schiess13,
  14. Elaine R. Peskind6,7,
  15. Masami Masuda14,
  16. Masato Hasegawa14,
  17. Xiangmin Lin1,
  18. Catherine Pan1,
  19. Douglas Galasko15,
  20. David S. Goldstein16,
  21. Poul Henning Jensen17,
  22. Hui Yang1,
  23. Kevin C. Cain18 and
  24. Jing Zhang1,
  1. 1Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA.
  2. 2Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
  3. 3Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA.
  4. 4Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
  5. 5Department of Neurology, University of Washington School of Medicine, Seattle, WA 98104, USA.
  6. 6Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98105, USA.
  7. 7Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
  8. 8Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany.
  9. 9German Center for Neurodegenerative Diseases, University of Tuebingen, 72076 Tuebingen, Germany.
  10. 10Institute on Aging, Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  11. 11Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19107, USA.
  12. 12Division of Movement Disorders, University of Louisville School of Medicine, Louisville, KY 40202, USA.
  13. 13Department of Neurology, University of Texas Health Science Center, Houston, TX 77030, USA.
  14. 14Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8585, Japan.
  15. 15Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA.
  16. 16Clinical Neurocardiology Section, Community Networks Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
  17. 17Department of Medical Chemistry, Aarhus University, 8000 Aarhus C, Denmark.
  18. 18Department of Biostatistics, University of Washington, Seattle, WA 98105, USA.
  1. To whom correspondence should be addressed. E-mail: zhangj{at}uw.edu
  • * These authors contributed equally to this work.

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