Research ArticleFibrosis

MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways

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Science Translational Medicine  15 Feb 2012:
Vol. 4, Issue 121, pp. 121ra18
DOI: 10.1126/scitranslmed.3003205

Article Information

vol. 4 no. 121 121ra18

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 13, 2011
  • Accepted for publication January 23, 2012
  • .

Author Information

  1. B. Nelson Chau1,*,
  2. Cuiyan Xin2,
  3. Jochen Hartner3,4,
  4. Shuyu Ren2,
  5. Ana P. Castano4,
  6. Geoffrey Linn2,
  7. Jian Li1,
  8. Phong T. Tran1,
  9. Vivek Kaimal1,
  10. Xinqiang Huang1,
  11. Aaron N. Chang1,
  12. Shenyang Li5,
  13. Aarti Kalra6,
  14. Monica Grafals7,8,
  15. Didier Portilla5,
  16. Deidre A. MacKenna1,
  17. Stuart H. Orkin3,4 and
  18. Jeremy S. Duffield2,*
  1. 1Regulus Therapeutics, San Diego, CA 92121, USA.
  2. 2Division of Nephrology, Center for Lung Biology, Department of Medicine, and Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.
  3. 3Dana-Farber Cancer Institute, Children’s Hospital, Boston, MA 02215, USA.
  4. 4Harvard Medical School, Boston, MA 02215, USA.
  5. 5Division of Nephrology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
  6. 6Division of Pathology, Lahey Clinic Medical Center, Burlington, MA 01805, USA
  7. 7Division of Transplantation, Lahey Clinic Medical Center, Burlington, MA 01805, USA.
  8. 8Tufts University, Boston, MA 02110, USA.
  1. *To whom correspondence should be addressed. E-mail: jeremysd{at}u.washington.edu (J.S.D.); nchau{at}regulusrx.com (B.N.C.)

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