LetterMolecular Imaging

Response to Comment on “Rapid Cancer Detection by Topically Spraying a γ-Glutamyltranspeptidase–Activated Fluorescent Probe”

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Science Translational Medicine  15 Feb 2012:
Vol. 4, Issue 121, pp. 121lr1
DOI: 10.1126/scitranslmed.3003757

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It takes considerable time and effort to create a successful imaging agent for clinical translation. In general, there are two approaches to developing new agents—bottom-up and top-down—which we compare here.

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