Research ArticleCancer

Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers

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Science Translational Medicine  08 Feb 2012:
Vol. 4, Issue 120, pp. 120ra17
DOI: 10.1126/scitranslmed.3003316

Article Information

vol. 4 no. 120 120ra17

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 11, 2011
  • Accepted for publication January 18, 2012
  • .

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Author Information

  1. Ryohei Katayama1,2,*,
  2. Alice T. Shaw1,2,3,*,
  3. Tahsin M. Khan1,3,
  4. Mari Mino-Kenudson2,4,
  5. Benjamin J. Solomon5,
  6. Balazs Halmos6,
  7. Nicholas A. Jessop1,
  8. John C. Wain1,7,
  9. Alan Tien Yeo1,
  10. Cyril Benes1,2,
  11. Lisa Drew8,
  12. Jamal Carlos Saeh8,
  13. Katherine Crosby9,
  14. Lecia V. Sequist1,2,
  15. A. John Iafrate2,4 and
  16. Jeffrey A. Engelman1,2,
  1. 1Massachusetts General Hospital Cancer Center, Boston, MA 02129, USA.
  2. 2Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  3. 3Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  4. 4Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
  5. 5Peter MacCallum Cancer Center, East Melbourne, Victoria 3002, Australia.
  6. 6Columbia University Medical Center, New York City, NY 10032, USA.
  7. 7Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
  8. 8AstraZeneca R&D Boston, Waltham, MA 02451, USA.
  9. 9Cell Signaling Technology Inc., Danvers, MA 01923, USA.
  1. To whom correspondence should be addressed. E-mail: jengelman{at}partners.org
  • * These authors contributed equally to this work.

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