Contents

Contents

• Focus

  • Improving Immunotherapy: Revisiting the Immunologist’s Little Secret

    By Jay A. Berzofsky

    Science Translational Medicine08 Feb 2012 : 120fs4 Full AccessRestricted Access

    Synergy between intracellular and extracellular sensing mechanisms of the innate immune system improves adaptive immune responses to cancer vaccines and clearance of tumors.

    • Abstract
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• Perspective

  • Escaping ALK Inhibition: Mechanisms of and Strategies to Overcome Resistance

    By Christine M. Lovly, William Pao

    Science Translational Medicine08 Feb 2012 : 120ps2 Full AccessRestricted Access

    Two recent studies offer insights on how cancer cells develop resistance to targeted therapies and possible ways to battle this therapeutic bottleneck.

    • Abstract
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• Research Articles

  • AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness

    By Jean Bennett, Manzar Ashtari, Jennifer Wellman, Kathleen A. Marshall, Laura L. Cyckowski, Daniel C. Chung, Sarah McCague, Eric A. Pierce, Yifeng Chen, Jeannette L. Bennicelli, Xiaosong Zhu, Gui-shuang Ying, Junwei Sun, J. Fraser Wright, Alberto Auricchio, Francesca Simonelli, Kenneth S. Shindler, Federico Mingozzi, Katherine A. High, Albert M. Maguire

    Science Translational Medicine08 Feb 2012 : 120ra15 Full AccessRestricted Access

    Repeat administration of gene therapy to the contralateral retina of three congenitally blind patients was safe and resulted in improved vision.

    • Editor's Summary
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  • Simultaneous Targeting of Toll- and Nod-Like Receptors Induces Effective Tumor-Specific Immune Responses

    By Johan Garaude, Andrew Kent, Nico van Rooijen, J. Magarian Blander

    Science Translational Medicine08 Feb 2012 : 120ra16 Full AccessRestricted Access

    A cancer vaccine of irradiated tumor cells expressing flagellin primes effective NLRC4/NAIP5- and TLR5-dependent antitumor immune responses.

    • Editor's Summary
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  • Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers

    By Ryohei Katayama, Alice T. Shaw, Tahsin M. Khan, Mari Mino-Kenudson, Benjamin J. Solomon, Balazs Halmos, Nicholas A. Jessop, John C. Wain, Alan Tien Yeo, Cyril Benes, Lisa Drew, Jamal Carlos Saeh, Katherine Crosby, Lecia V. Sequist, A. John Iafrate, Jeffrey A. Engelman

    Science Translational Medicine08 Feb 2012 : 120ra17 Full AccessRestricted Access

    Multiple mechanisms of crizotinib resistance were identified in lung cancer patients including new secondary ALK mutations and activation of receptor tyrosine kinases.

    • Editor's Summary
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• Editors' Choice

  • Treatments for Atrial Fibrillation Get Personal

    By Samir Damani

    Science Translational Medicine08 Feb 2012 : 120ec19 Full AccessRestricted Access

    A pharmacogenomics study identifies a patient population that responds more favorably to heart rate–control medication.

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  • Mayday, Mayday, Mayday! Answering the Distress Call of the β Cell

    By Carmella Evans-Molina

    Science Translational Medicine08 Feb 2012 : 120ec20 Full AccessRestricted Access

    A noninvasive method to measure β-cell death in humans is based on differential epigenetic marks in the insulin promoter.

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  • Antibodies on the Brain

    By Richard J. Lin

    Science Translational Medicine08 Feb 2012 : 120ec21 Full AccessRestricted Access

    The central nervous system produces autoantibodies that may be used as markers for multiple sclerosis.

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  • Eye-Opening Experience

    By Christopher Skelly

    Science Translational Medicine08 Feb 2012 : 120ec22 Full AccessRestricted Access

    Gene therapy preserves the structure and function of photoreceptors in the eyes of dogs that model a human genetic eye disease that leads to incurable blindness.

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  • Bubble, Bubble, Tumor in Trouble

    By Srini Tridandapani

    Science Translational Medicine08 Feb 2012 : 120ec23 Full AccessRestricted Access

    Microbubble contrast-enhanced ultrasound can disrupt tumor blood vessels and results in tumor necrosis.

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• Podcast

  • Science Translational Medicine Podcast: 8 February 2012

    By Jeffrey Engelman, Orla Smith

    Science Translational Medicine08 Feb 2012 : 120pc2 Full AccessRestricted Access

    A conversation with Jeffrey Engelman about teasing apart the different molecular mechanisms that result in drug resistance in lung cancer patients.

    • Abstract