Contents
Vol 4, Issue 120
Contents
Focus
- Improving Immunotherapy: Revisiting the Immunologist’s Little Secret
Synergy between intracellular and extracellular sensing mechanisms of the innate immune system improves adaptive immune responses to cancer vaccines and clearance of tumors.
Perspective
- Escaping ALK Inhibition: Mechanisms of and Strategies to Overcome Resistance
Two recent studies offer insights on how cancer cells develop resistance to targeted therapies and possible ways to battle this therapeutic bottleneck.
Research Articles
- AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness
Repeat administration of gene therapy to the contralateral retina of three congenitally blind patients was safe and resulted in improved vision.
- Simultaneous Targeting of Toll- and Nod-Like Receptors Induces Effective Tumor-Specific Immune Responses
A cancer vaccine of irradiated tumor cells expressing flagellin primes effective NLRC4/NAIP5- and TLR5-dependent antitumor immune responses.
- Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers
Multiple mechanisms of crizotinib resistance were identified in lung cancer patients including new secondary ALK mutations and activation of receptor tyrosine kinases.
Editors' Choice
- Treatments for Atrial Fibrillation Get Personal
A pharmacogenomics study identifies a patient population that responds more favorably to heart rate–control medication.
- Mayday, Mayday, Mayday! Answering the Distress Call of the β Cell
A noninvasive method to measure β-cell death in humans is based on differential epigenetic marks in the insulin promoter.
- Antibodies on the Brain
The central nervous system produces autoantibodies that may be used as markers for multiple sclerosis.
- Eye-Opening Experience
Gene therapy preserves the structure and function of photoreceptors in the eyes of dogs that model a human genetic eye disease that leads to incurable blindness.
- Bubble, Bubble, Tumor in Trouble
Microbubble contrast-enhanced ultrasound can disrupt tumor blood vessels and results in tumor necrosis.
Podcast
- Science Translational Medicine Podcast: 8 February 2012
A conversation with Jeffrey Engelman about teasing apart the different molecular mechanisms that result in drug resistance in lung cancer patients.
