Research ArticleBrain Imaging

Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

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Science Translational Medicine  11 Jan 2012:
Vol. 4, Issue 116, pp. 116ra4
DOI: 10.1126/scitranslmed.3002693

Article Information

vol. 4 no. 116 116ra4

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication May 23, 2011
  • Accepted for publication November 23, 2011
  • .

Author Information

  1. Ovidiu C. Andronesi1,*,
  2. Grace S. Kim1,
  3. Elizabeth Gerstner2,
  4. Tracy Batchelor2,
  5. Aria A. Tzika1,3,
  6. Valeria R. Fantin4,
  7. Matthew G. Vander Heiden5,6 and
  8. A. Gregory Sorensen1
  1. 1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  2. 2Pappas Center for Neuro-Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  3. 3NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriners Burn Institute, Harvard Medical School, Boston, MA 02114, USA.
  4. 4Agios Pharmaceuticals, Cambridge, MA 02139, USA.
  5. 5Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  6. 6Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  1. *To whom correspondence should be addressed. E-mail: ovidiu{at}nmr.mgh.harvard.edu

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