Contents

Contents

• Perspective

  • Magnetic Resonance Metabolic Imaging of Glioma

    By Philippe Metellus, Dominique Figarella-Branger

    Science Translational Medicine11 Jan 2012 : 116ps1 Full AccessRestricted Access

    Noninvasive spectroscopic imaging of mutated enzymes and their metabolites could represent a new paradigm in glial tumor management.

    • Abstract
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• Research Articles

  • Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

    By Ovidiu C. Andronesi, Grace S. Kim, Elizabeth Gerstner, Tracy Batchelor, Aria A. Tzika, Valeria R. Fantin, Matthew G. Vander Heiden, A. Gregory Sorensen

    Science Translational Medicine11 Jan 2012 : 116ra4 Full AccessRestricted Access

    2-Hydroxyglutarate, a metabolite overproduced in IDH-mutated gliomas, can be detected noninvasively in patients with brain tumors by optimized magnetic resonance spectroscopy.

    • Editor's Summary
    • Abstract
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  • Magnetic Resonance of 2-Hydroxyglutarate in IDH1-Mutated Low-Grade Gliomas

    By Adam Elkhaled, Llewellyn E. Jalbert, Joanna J. Phillips, Hikari A. I. Yoshihara, Rupa Parvataneni, Radhika Srinivasan, Gabriela Bourne, Mitchel S. Berger, Susan M. Chang, Soonmee Cha, Sarah J. Nelson

    Science Translational Medicine11 Jan 2012 : 116ra5 Full AccessRestricted Access

    2-Hydroxyglutarate can be detected ex vivo in biopsy tissue from IDH1-mutant low-grade gliomas with proton high-resolution magic angle spinning NMR spectroscopy.

    • Editor's Summary
    • Abstract
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  • Alcohol Consumption Induces Endogenous Opioid Release in the Human Orbitofrontal Cortex and Nucleus Accumbens

    By Jennifer M. Mitchell, James P. O’Neil, Mustafa Janabi, Shawn M. Marks, William J. Jagust, Howard L. Fields

    Science Translational Medicine11 Jan 2012 : 116ra6 Full AccessRestricted Access

    Endogenous opioids are released in reward-related brain areas after an alcoholic drink to a greater extent in heavy drinkers than in control subjects.

    • Editor's Summary
    • Abstract
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• Editors' Choice

  • Building a Preventive Medicine Model with Genetic Scoring

    By Samir Damani

    Science Translational Medicine11 Jan 2012 : 116ec4 Full AccessRestricted Access

    A new genetic risk score promises personalized risk prediction for cardiovascular disease in diabetics.

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  • A New FIX for Hemophilia B

    By Carmella Evans-Molina

    Science Translational Medicine11 Jan 2012 : 116ec5 Full AccessRestricted Access

    An improved gene therapy strategy results in an encouraging reduction in factor IX infusions for hemophilia B patients.

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  • The Holy Grail of Hepatitis C Treatment

    By Richard J. Lin

    Science Translational Medicine11 Jan 2012 : 116ec6 Full AccessRestricted Access

    A model predicts sustained virological response to hepatitis C treatment.

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  • Measles Versus Melanoma

    By Christopher Skelly

    Science Translational Medicine11 Jan 2012 : 116ec7 Full AccessRestricted Access

    A measles vaccine virus modulates the innate immune system and promotes virus-mediated death of malignant melanoma cells.

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