Contents
Vol 4, Issue 115
Contents
Focus
- Chimp Virus Makes a Savvy Vaccine Vector
A hepatitis C virus vaccine delivered by a chimpanzee-derived adenovirus vector produces strong cellular immune responses in healthy human volunteers.
Research Articles
- Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man
An adenoviral HCV vaccine induces antiviral T cell responses in human volunteers.
- Vaccine Vectors Derived from a Large Collection of Simian Adenoviruses Induce Potent Cellular Immunity Across Multiple Species
Simian adenoviruses screened from wild-derived candidates can prime T cell responses in man and may serve as new vaccine vector candidates.
- Paracrine Signaling Through MYCN Enhances Tumor-Vascular Interactions in Neuroblastoma
PI3K/mTOR inhibitors inhibit angiogenesis by blocking MYCN-dependent paracrine signaling between tumor and endothelial cells.
Review
- NEW: Network-Enabled Wisdom in Biology, Medicine, and Health Care
Multidimensional networks are required to model human physiology in general and to identify key drivers of pathology in individual patients.
Editors' Choice
- Triple Whammy
Tripartite vaccine generates antibody and cellular immune responses to tumor-associated MUC1.
- How Do You Handle Your Antibodies?
Genome-wide association study of a rare complex disease implicates an immunoglobulin receptor variant.
- A Less Controversial Colon Cleanser?
A computerized form of colon cleansing might increase public compliance with cancer screening guidelines.
Podcast
- Science Translational Medicine Podcast: 4 January 2012
A conversation with Alfredo Nicosia about the discovery of new adenoviruses that will help to make better vaccines to treat human diseases.
