Hidden Immunotherapy Targets Challenge Dogma

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Science Translational Medicine  07 Sep 2011:
Vol. 3, Issue 99, pp. 99ps38
DOI: 10.1126/scitranslmed.3002821

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In this issue of Science Translational Medicine, Guo et al. discuss the intriguing possibility that intracellular tumor antigen–specific monoclonal antibodies (mAbs) inhibit tumor growth and metastasis and prolong survival of tumor-bearing mice. Here, I discuss the implications of using intracellular targets in mAb-based immunotherapy as well as the possible underlying mechanisms of action.


  • Citation: S. Ferrone, Hidden Immunotherapy Targets Challenge Dogma. Sci. Transl. Med. 3, 99ps38 (2011).

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