24 August 2011
Vol 3, Issue 97

About The Cover

Cover image expansion

ONLINE COVER Seeing Is Believing. The crystal structure of transthyretin, a tetrameric protein that carries the thyroid-hormone precursor thyroxine through the blood. An inhibitor (gray) is shown in the transthyretin-binding pocket (blue), located at the interface between two monomers. Inhibitor binding stabilizes the tetramer, preventing the monomers from forming disease-causing amyloid aggregates, as described by Alhamashed et al. Transthyretin amyloid tends to accumulate in the heart, causing serious cardiomyopathy. [CREDIT: S. CONNELLY]