Contents
Vol 3, Issue 96
Contents
Commentaries
- Evaluating Preclinical Efficacy
Translation of modern type 1 diabetes treatments from mouse to humans depends on implementation of therapeutic efficacy standards.
- Biomedical Innovation: A Risky Business at Risk
Biomedical innovation needs a new regulatory framework that better balances the benefits and risks to the public of pioneering products.
Perspective
- The Emergence of Genome-Based Drug Repositioning
Genome-wide methods of mRNA signature analyses permit the high-throughput evaluation of medications for drug repurposing.
Research Articles
- Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease
Computationally predicted repositioning of an anticonvulsant for inflammatory bowel disease is confirmed experimentally.
- Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data
A systematic computational method predicts new uses for existing drugs by integrating public gene expression signatures of drugs and diseases.
- Stem Cell–Mediated Transfer of a Human Artificial Chromosome Ameliorates Muscular Dystrophy
Combining gene delivery using a human artificial chromosome with stem cell transplantation ameliorates muscular dystrophy in a mouse model.
Editors' Choice
- Decoding Schizophrenia
Exome sequencing illuminates the genetic landscape of schizophrenia.
- A Snooze Button for the Biological Clock
Age-specific anti-Müllerian hormone concentrations can predict the future age of menopause.
- Too Much of a Good Thing
Mutations in a key enzyme in a calcium signaling pathway shed light on the genetic basis of a vitamin D sensitivity disorder.
- Healing Achilles’ Heel
Self-assembling filamentous peptide nanofibers promote therapeutic angiogenesis.
