Contents
Vol 3, Issue 95
Contents
Focus
- Type 1 Diabetes Immunotherapy: Is the Glass Half Empty or Half Full?
The islet cell preservation observed in immunotherapy clinical trials should motivate the type 1 diabetes community.
Commentary
- Core Facilities: Maximizing the Return on Investment
State-of-the-art clinical and translational research requires specialized core facilities with highly trained staff.
Perspective
- Cancer Drug Discovery Faces the FACT
A second chromatin-remodeling factor—after the histone deacetylases—may serve as a versatile therapeutic target for cancer.
Research Articles
- T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia
Adoptively transferred gene-modified T cells expand in vivo, eliminate leukemic cells, and form functional memory cells in patients.
- Curaxins: Anticancer Compounds That Simultaneously Suppress NF-κB and Activate p53 by Targeting FACT
The quinacrine-related compounds curaxins target multiple procancer pathways through FACT complex.
- Rare Copy Number Variation Discovery and Cross-Disorder Comparisons Identify Risk Genes for ADHD
A high-resolution analysis of copy number variation in patients with ADHD reveals new gene associations, few de novo mutations, and overlap with genes implicated in other disorders such as autism.
Editors' Choice
- Finding a Needle in a Haystack
A new microarray-based prenatal test identifies DNA microdeletions that may be missed by standard cytogenetics analyses.
- The Root of All “Bad” Cholesterol
Rare and population-specific variants in LDL cholesterol genes explain double the heritability over common tagging variants.
- Getting Past the Bullies
An oral nanoformulation of docetaxel protects the drug from intestinal efflux and metabolism.
- Stabilizing the Kidney’s Skeleton
Coding-change variants in the MYO1E gene disrupt podocyte function and cause focal segmental glomerulosclerosis.
- Johnny, Johnny, Eating Sugar?
A new kind of sugar-based bait can be used to detect bacterial infections early.
