10 August 2011
Vol 3, Issue 95

About The Cover

Cover image expansion

ONLINE COVER Does Not Disturb. In general, DNA-inserting cancer drugs damage DNA, which spurs mutagenesis and induces cell death. Now, Gasparian et al. highlight a subtler class of small molecules called curaxins that nestle in the minor groove of DNA (shown here in blue) and block tumor cell growth without inducing DNA breaks or mutations. Instead, curaxins cause a conformational change in the DNA that invites entry of the chromatin-remodeling FACT complex (red); the stress-activated transcription factor NK-κB is inhibited, and p53 is activated by CK2 (green) phosphorylation. See also the accompanying Perspective by Draetta and DePinho. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]