Contents
Vol 3, Issue 93
Contents
Commentary
- Losing the War Against Obesity: The Need for a Developmental Perspective
Recent scientific insights into early-life contributions to the adult obesity epidemic must now be translated into interventions.
Perspective
- Antibody Repertoire: Embracing Diversity
Adjuvanted formulations expand the vaccine-induced antibody repertoires against a virus and a parasite.
Research Articles
- Photoactivated Composite Biomaterial for Soft Tissue Restoration in Rodents and in Humans
Photoactivated composite poly(ethylene glycol)–hyaluronic acid biomaterials demonstrate enhanced physicochemical properties for facial soft tissue reconstruction.
- IL-7 Promotes TH1 Development and Serum IL-7 Predicts Clinical Response to Interferon-β in Multiple Sclerosis
High serum IL-7 predicts responsiveness of multiple sclerosis patients to IFN-β therapy and indicates a TH1 cell–driven disease.
- Targeting TLRs Expands the Antibody Repertoire in Response to a Malaria Vaccine
The use of TLR agonists in vaccination broadens the range of polymorphic variants against which the antibodies can be effective.
Review
- Assessing the Safety of Adjuvanted Vaccines
Preclinical and clinical studies assess the risk of adverse events from vaccine adjuvants.
Editors' Choice
- Bioinformatics Is “HIP” in the Islets
Combing GWAS data for disease-relevant interacting proteins predicts a role for HIP14 in diabetes.
- Preventing HIV Transmission: Early Therapy Is Key
Early combination antiretroviral drug therapy reduces virus transmission to the uninfected partner in HIV serodiscordant couples.
- Speaking from the Mind
A new communication assist device deciphers speech directly from cortical activity.
- A Death by a Thousand Cuts
Nearly 4% of lung cancers exhibit mutations in the DDR2 kinase gene and are susceptible to dasatinib, adding to the 14% that are already known to respond to this drug.
