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Research ArticleHuman Genetics
A Common Mutation in the Defensin DEFB126 Causes Impaired Sperm Function and Subfertility
- Theodore L. Tollner1,*,
- Scott A. Venners2,*,
- Edward J. Hollox3,
- Ashley I. Yudin4,
- Xue Liu5,
- Genfu Tang5,
- Houxun Xing5,
- Robert J. Kays6,
- Tsang Lau6,
- James W. Overstreet4,
- Xiping Xu7,
- Charles L. Bevins6,* and
- Gary N. Cherr8,*,†
- 1Department of Obstetrics and Gynecology, School of Medicine, University of California, Davis, CA 95817, USA.
- 2Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
- 3Department of Genetics, University of Leicester, LE1 7RH Leicester, UK.
- 4Center for Health and the Environment, University of California, Davis, CA 95616, USA.
- 5Institute for Biomedicine, Anhui Medical University, Hefei 0551-5161014, China.
- 6Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
- 7School of Public Health, University of Illinois, Chicago, IL 60612, USA.
- 8Departments of Environmental Toxicology and Nutrition, Bodega Marine Laboratory, University of California, Davis, CA 95616, USA.
- ↵†To whom correspondence should be addressed. E-mail: gncherr{at}ucdavis.edu
-
↵* These authors contributed equally to this work.
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Science Translational Medicine 20 Jul 2011:
Vol. 3, Issue 92, pp. 92ra65
DOI: 10.1126/scitranslmed.3002289
Vol. 3, Issue 92, pp. 92ra65
DOI: 10.1126/scitranslmed.3002289
Theodore L. Tollner
Department of Obstetrics and Gynecology, School of Medicine, University of California, Davis, CA 95817, USA.
Scott A. Venners
Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Edward J. Hollox
Department of Genetics, University of Leicester, LE1 7RH Leicester, UK.
Ashley I. Yudin
Center for Health and the Environment, University of California, Davis, CA 95616, USA.
Xue Liu
Institute for Biomedicine, Anhui Medical University, Hefei 0551-5161014, China.
Genfu Tang
Institute for Biomedicine, Anhui Medical University, Hefei 0551-5161014, China.
Houxun Xing
Institute for Biomedicine, Anhui Medical University, Hefei 0551-5161014, China.
Robert J. Kays
Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
Tsang Lau
Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
James W. Overstreet
Center for Health and the Environment, University of California, Davis, CA 95616, USA.
Xiping Xu
School of Public Health, University of Illinois, Chicago, IL 60612, USA.
Charles L. Bevins
Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
Gary N. Cherr
Departments of Environmental Toxicology and Nutrition, Bodega Marine Laboratory, University of California, Davis, CA 95616, USA.
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