Research ArticleHeart Disease

Cardiac AAV9-S100A1 Gene Therapy Rescues Post-Ischemic Heart Failure in a Preclinical Large Animal Model

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Science Translational Medicine  20 Jul 2011:
Vol. 3, Issue 92, pp. 92ra64
DOI: 10.1126/scitranslmed.3002097

Article Information

vol. 3 no. 92 92ra64

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 3, 2011
  • Accepted for publication June 30, 2011
  • .

Author Information

  1. Sven T. Pleger1,2,
  2. Changguang Shan1,2,
  3. Jan Ksienzyk2,
  4. Raffi Bekeredjian2,
  5. Peter Boekstegers3,
  6. Rabea Hinkel3,
  7. Stefanie Schinkel2,
  8. Barbara Leuchs4,
  9. Jochen Ludwig5,
  10. Gang Qiu6,
  11. Christophe Weber1,2,
  12. Philip Raake2,
  13. Walter J. Koch7,
  14. Hugo A. Katus2,
  15. Oliver J. Müller2,* and
  16. Patrick Most1,2,6,*
  1. 1Center for Molecular and Translational Cardiology, University of Heidelberg, 69120 Heidelberg, Germany.
  2. 2Department of Internal Medicine III, Division of Cardiology, INF 350, University of Heidelberg, 69120 Heidelberg, Germany.
  3. 3Internal Medicine I, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, 81377 Munich, Germany.
  4. 4Applied Tumour Virology, German Cancer Research Center, INF 242, 69120 Heidelberg, Germany.
  5. 5Department of Internal Medicine I and Clinical Chemistry, INF 410, University of Heidelberg, 69120 Heidelberg, Germany.
  6. 6Laboratory for Cardiac Stem Cell and Gene Therapy, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
  7. 7George Zallie and Family Laboratory for Cardiovascular Gene Therapy, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
  1. To whom correspondence should be addressed. E-mail: patrick.most{at}med.uni-heidelberg.de (P.M.); oliver.mueller{at}med.uni-heidelberg.de (O.J.M.)

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