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Abstract
Antiretroviral therapy has improved the quality and length of life of millions of individuals affected by human immunodeficiency virus type 1 (HIV-1). The capacity of these drugs to indefinitely suppress HIV—which has a well-known capacity for escaping antiviral pressures—is surprising. In this issue of Science Translational Medicine, Shen et al. use a combination of mathematical modeling and experiment to examine the potency of anti-HIV drugs. They show that non-nucleoside reverse transcriptase inhibitors and protease inhibitors exhibit cooperative dose-response curves—a finding that has implications for the treatment of HIV as well as other viral infections, such as hepatitis C.
Footnotes
Citation: A. S. Perelson, S. G. Deeks, Drug Effectiveness Explained: The Mathematics of Antiviral Agents for HIV. Sci. Transl. Med. 3, 91ps30 (2011).
- Copyright © 2011, American Association for the Advancement of Science
