Contents
Vol 3, Issue 90
Contents
Commentary
- Reengineering Translational Science: The Time Is Right
The new National Center for Advancing Translational Sciences aims to revamp the process of biomedical research translation.
Perspective
- Development of Newborn and Infant Vaccines
Insights into immune ontogeny will inform translation of new vaccines that are safe and effective for newborns and infants.
Research Articles
- Optimization of Dosing for EGFR-Mutant Non–Small Cell Lung Cancer with Evolutionary Cancer Modeling
Predictive models of EGFR-mutant tumor behavior point to alternative drug dosing strategies to prevent and treat acquired resistance.
- CXCL5 Mediates UVB Irradiation–Induced Pain
The cytokine CXCL5 is a peripheral mediator of pain induced by UVB irradiation to the skin.
- Deep Sequencing of the Human TCRγ and TCRβ Repertoires Suggests that TCRβ Rearranges After αβ and γδ T Cell Commitment
Deep sequencing provides new insights about T cell receptor rearrangement in humans.
Editors' Choice
- Sunshine Vitamin Sheds Light on MS
A randomized controlled trial of high-dose vitamin D in multiple sclerosis patients correlates reduced T cell reactivity with clinical benefit.
- A Curious Case of Cellular Metabolism
Understanding how reprogramming induces a cancer cell–like metabolic signature in stem cells may yield drugs that target tumor metabolism.
- The Autistic Brain: Out of Synch?
Autism in toddlers is associated with decreased synchronization of brain regions involved in language.
- Inkjet Pharmacy
Inkjet printer technology can accurately dispense individualized drug doses on demand.
- A Mimic for Lupus Treatment
Peptidomimetics can function as highly specific, targeted treatments for systemic lupus erythematosus without generalized immunosuppression.