Contents

Contents

• Commentary

  • Reengineering Translational Science: The Time Is Right

    By Francis S. Collins

    Science Translational Medicine06 Jul 2011 : 90cm17 Full AccessRestricted Access

    The new National Center for Advancing Translational Sciences aims to revamp the process of biomedical research translation.

    • Abstract
    • Full Text
    • PDF

• Perspective

  • Development of Newborn and Infant Vaccines

    By Guzman Sanchez-Schmitz, Ofer Levy

    Science Translational Medicine06 Jul 2011 : 90ps27 Full AccessRestricted Access

    Insights into immune ontogeny will inform translation of new vaccines that are safe and effective for newborns and infants.

    • Abstract
    • Full Text
    • PDF

• Research Articles

  • Optimization of Dosing for EGFR-Mutant Non–Small Cell Lung Cancer with Evolutionary Cancer Modeling

    By Juliann Chmielecki, Jasmine Foo, Geoffrey R. Oxnard, Katherine Hutchinson, Kadoaki Ohashi, Romel Somwar, Lu Wang, Katherine R. Amato, Maria Arcila, Martin L. Sos, Nicholas D. Socci, Agnes Viale, Elisa de Stanchina, Michelle S. Ginsberg, Roman K. Thomas, Mark G. Kris, Akira Inoue, Marc Ladanyi, Vincent A. Miller, Franziska Michor, William Pao

    Science Translational Medicine06 Jul 2011 : 90ra59 Full AccessRestricted Access

    Predictive models of EGFR-mutant tumor behavior point to alternative drug dosing strategies to prevent and treat acquired resistance.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • CXCL5 Mediates UVB Irradiation–Induced Pain

    By John M. Dawes, Margarita Calvo, James R. Perkins, Kathryn J. Paterson, Hannes Kiesewetter, Carl Hobbs, Timothy K. Y. Kaan, Christine Orengo, David L. H. Bennett, Stephen B. McMahon

    Science Translational Medicine06 Jul 2011 : 90ra60 Full AccessRestricted Access

    The cytokine CXCL5 is a peripheral mediator of pain induced by UVB irradiation to the skin.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Deep Sequencing of the Human TCRγ and TCRβ Repertoires Suggests that TCRβ Rearranges After αβ and γδ T Cell Commitment

    By Anna M. Sherwood, Cindy Desmarais, Robert J. Livingston, Jessica Andriesen, Maximilian Haussler, Christopher S. Carlson, Harlan Robins

    Science Translational Medicine06 Jul 2011 : 90ra61 Full AccessRestricted Access

    Deep sequencing provides new insights about T cell receptor rearrangement in humans.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Sunshine Vitamin Sheds Light on MS

    By Rebecca S. Boxer

    Science Translational Medicine06 Jul 2011 : 90ec102 Full AccessRestricted Access

    A randomized controlled trial of high-dose vitamin D in multiple sclerosis patients correlates reduced T cell reactivity with clinical benefit.

    • Abstract

  • A Curious Case of Cellular Metabolism

    By Ashkan Emadi

    Science Translational Medicine06 Jul 2011 : 90ec103 Full AccessRestricted Access

    Understanding how reprogramming induces a cancer cell–like metabolic signature in stem cells may yield drugs that target tumor metabolism.

    • Abstract

  • The Autistic Brain: Out of Synch?

    By George A. Mashour

    Science Translational Medicine06 Jul 2011 : 90ec104 Full AccessRestricted Access

    Autism in toddlers is associated with decreased synchronization of brain regions involved in language.

    • Abstract

  • Inkjet Pharmacy

    By Erik Rytting

    Science Translational Medicine06 Jul 2011 : 90ec105 Full AccessRestricted Access

    Inkjet printer technology can accurately dispense individualized drug doses on demand.

    • Abstract

  • A Mimic for Lupus Treatment

    By Anthony K. Shum

    Science Translational Medicine06 Jul 2011 : 90ec106 Full AccessRestricted Access

    Peptidomimetics can function as highly specific, targeted treatments for systemic lupus erythematosus without generalized immunosuppression.

    • Abstract