Research ArticleProgeria

Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

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Science Translational Medicine  29 Jun 2011:
Vol. 3, Issue 89, pp. 89ra58
DOI: 10.1126/scitranslmed.3002346

Article Information

vol. 3 no. 89 89ra58

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 3, 2011
  • Accepted for publication June 2, 2011
  • .

Author Information

  1. Kan Cao1,2,*,
  2. John J. Graziotto3,*,
  3. Cecilia D. Blair1,
  4. Joseph R. Mazzulli3,
  5. Michael R. Erdos1,
  6. Dimitri Krainc3, and
  7. Francis S. Collins1,
  1. 1Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892–8004, USA.
  2. 2Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
  3. 3Department of Neurology, Massachusetts General Hospital, MassGeneral Institute for Neurodegenerative Disease, Harvard Medical School, Charlestown, MA 02129, USA.
  1. To whom correspondence should be addressed. E-mail: francis.collins{at}nih.gov (F.S.C.); krainc{at}helix.mgh.harvard.edu (D.K.)

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