Contents
Vol 3, Issue 89
Contents
Commentaries
- The Fiber of Modern Society
In a series of articles, diverse professionals engage in a critical dialogue on innovation.
- Repaving the Road to Biomedical Innovation Through Academia
New funding models that support high-risk research in academia will spur innovation.
- How to Revive Breakthrough Innovation in the Pharmaceutical Industry
Pharmaceutical firms must reengage in high-risk discovery research and only take genuine breakthroughs to the clinic.
Research Articles
- Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance
Human apoE4 increases the concentration of soluble Aβ in the brain by impairing its clearance.
- Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells
Shown previously to extend longevity in animals, the drug rapamycin might serve as a treatment for a human premature aging syndrome.
Editors' Choice
- The Nerve of Those β Cells
The α cells of the human pancreas secrete acetylcholine that regulates insulin secretion.
- A Hair-Raising Finding in Leukemia
The discovery of a BRAF kinase mutation in hairy cell leukemia suggests that a BRAF kinase inhibitor may be useful for treating this disease.
- HCV Homolog in Dog: A Scientist’s Best Friend
A new HCV homolog in dog provides the first nonprimate animal model for HCV therapeutics discovery.
- The Biodigital Brain
A computer chip that mimics the natural neuronal network can potentially bypass or replace damaged neuronal circuitry in the brain.
