29 June 2011
Vol 3, Issue 89

About The Cover

Cover image expansion

ONLINE COVER Thinking Differently. A 21st-century version of The Thinker—by French sculptor Auguste Rodin (1840–1917)—might ponder one of the quandaries of the day in translational biomedicine: Why have remarkable advances in basic biological science been so slow to be translated to improvements in clinical medicine? In a series of Commentaries—three in this issue by Edelman and Leon, Marks, Munos and Chin, and more in future issues—thought leaders from various segments of the biomedical community engage in critical analyses of the state of innovation. The authors muse on different mechanisms for resuscitating innovation, but a common thread emerges: A new mindset must drive risk-benefit analyses. [CREDIT: WESLEY VANDINTER/ISTOCKPHOTO]