Research ArticleGene Therapy

Dosage Thresholds for AAV2 and AAV8 Photoreceptor Gene Therapy in Monkey

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Science Translational Medicine  22 Jun 2011:
Vol. 3, Issue 88, pp. 88ra54
DOI: 10.1126/scitranslmed.3002103

Article Information

vol. 3 no. 88 88ra54

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 4, 2011
  • Accepted for publication June 3, 2011
  • .

Author Information

  1. Luk H. Vandenberghe1,*,
  2. Peter Bell1,
  3. Albert M. Maguire2,3,
  4. Cassia N. Cearley4,5,
  5. Ru Xiao1,
  6. Roberto Calcedo1,
  7. Lili Wang1,
  8. Michael J. Castle4,5,
  9. Alexandra C. Maguire2,,
  10. Rebecca Grant1,
  11. John H. Wolfe4,5,
  12. James M. Wilson1, and
  13. Jean Bennett2,3,
  1. 1Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  2. 2F. M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
  3. 3Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104 USA.
  4. 4W. F. Goodman Center for Comparative Medical Genetics, School of Veterinary Medicine and Department of Pediatrics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  5. 5Stokes Research Institute, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  1. To whom correspondence should be addressed. E-mail: wilsonjm{at}mail.med.upenn.edu (J.M.W.); jebennet{at}mail.med.upenn.edu (J.B.)

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