22 June 2011
Vol 3, Issue 88

About The Cover

Cover image expansion

ONLINE COVER Bad Breakup. The endoplasmic reticulum (ER, shown in blue) and mitochondria (yellow) usually form a power couple. Normally, under conditions of high or chronic stress, the ER signals to the mitochondria to initiate programmed cell death. But prolonged stress can put a strain on any relationship. In a mouse-model mimic of the disease pulmonary arterial hypertension (PAH), Sutendra et al. show that hypoxia-induced stress widened the gap between ER and mitochondria in vascular cells from the lung; in comparable mice that lacked the Nogo-B protein, ER and mitochondria didn't grow apart in stressful conditions. This suggests that depletion of Nogo-B protects against ER-mitochondria disruption in PAH, making Nogo-B a possible therapeutic target. See the accompanying Perspective by Muñoz and Zorzano. [CREDIT: Y. HAMMOND/SCIENCE TRANSLATIONAL MEDICINE]