Contents
Vol 3, Issue 87
Contents
Perspectives
- Deep Sequencing of Patient Genomes for Disease Diagnosis: When Will It Become Routine?
Deep sequencing of an individual patient's genome may become a common practice for precise clinical diagnosis.
- Breaking Free of Sample Size Dogma to Perform Innovative Translational Research
Abandoning false beliefs about sample-size planning would facilitate funding and conduct of innovative clinical research with small sample sizes.
Research Articles
- Inhibition of Transplantation Tolerance by Immune Senescence Is Reversed by Endocrine Modulation
Immune senescence causes resistance to transplantation tolerance that can be functionally restored by targeting sex steroid production.
- The Role of Dimethylarginine Dimethylaminohydrolase in Idiopathic Pulmonary Fibrosis
Inhibition of dimethylarginine dimethylaminohydrolase enzyme in lung attenuates two hallmarks of pulmonary fibrosis, excess cells and excess collagen, thereby offering a therapeutic approach.
Reports
- Whole-Genome Sequencing for Optimized Patient Management
A disease mutation identified by whole-genome sequencing of twins with dystonia allowed optimization of treatment, resulting in clinical improvements.
Editors' Choice
- Protecting the Protector
Targeting a metabolic enzyme in blood protects neurons in the brain and ameliorates symptoms in animal models of Alzheimer’s and Huntington’s disease.
- Testing Complex Genetic Interactions for Complex Diseases
A novel approach to testing for synergistic interactions among genes allows statistical analysis to accommodate hypotheses based on complex biological systems.
- Inheriting Disease Severity
Genome-wide association study identified genetic loci linked to increased disease severity in cystic fibrosis.
- Leave No Stone Unturned
Noninvasive imaging and characterization of kidney stones using computed tomography might lead to improved treatment.
