Research ArticleCancer

Off-Target Lapatinib Activity Sensitizes Colon Cancer Cells Through TRAIL Death Receptor Up-Regulation

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Science Translational Medicine  08 Jun 2011:
Vol. 3, Issue 86, pp. 86ra50
DOI: 10.1126/scitranslmed.3001384

Article Information

vol. 3 no. 86 86ra50

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 14, 2010
  • Accepted for publication May 12, 2011
  • .

Author Information

  1. Nathan G. Dolloff1,2,
  2. Patrick A. Mayes1,
  3. Lori S. Hart1,
  4. David T. Dicker1,2,
  5. Robin Humphreys3 and
  6. Wafik S. El-Deiry1,2,4,*
  1. 1Laboratory of Molecular Oncology and Cell Cycle Regulation, Departments of Medicine (Hematology/Oncology), Genetics, and Pharmacology, Institute for Translational Medicine and Therapeutics, Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  2. 2Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Medicine (Hematology/Oncology), Penn State Hershey Cancer Institute, Penn State Hershey Medical Center, Penn State College of Medicine, Hershey, PA 17033, USA.
  3. 3Oncology Research Department, Human Genome Sciences Inc., Rockville, MD 20850, USA.
  4. 4American Cancer Society, Atlanta, GA 30329, USA.
  1. *To whom correspondence should be addressed. E-mail: wafik.eldeiry{at}gmail.com

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