Contents
Vol 3, Issue 86
Contents
Perspective
- Transplantation Tolerance: Memories That Haunt Us
Screening for preformed donor-reactive memory T cells may advance the goal of organ transplant acceptance without immunosuppression.
Research Articles
- Protein Interactome Reveals Converging Molecular Pathways Among Autism Disorders
We developed an autism protein interaction network that provides a framework for studying autism pathogenesis and reveals shared molecular pathways among distinct autism spectrum disorders.
- Off-Target Lapatinib Activity Sensitizes Colon Cancer Cells Through TRAIL Death Receptor Up-Regulation
The breast cancer drug lapatinib increases the sensitivity of colon cancer cells to apoptosis through a HER2- and EGFR-independent mechanism.
- Host Alloreactive Memory T Cells Influence Tolerance to Kidney Allografts in Nonhuman Primates
Only nonhuman primates with low frequencies of donor-specific memory T cells develop tolerance and accept allogeneic kidney transplants.
Editors' Choice
- Building Hearts, One Cell at a Time
Mechanical stress and vascularization move immature human cardiomyocytes a step closer to forming functional heart tissue.
- Ramping Up a Cell’s Chemical Weapon
Genetically correcting induced pluripotent stem cells derived from a patient with chronic granulomatous disease demonstrates the feasibility of this therapeutic approach.
- When Light Gets On Your Nerves
After peripheral nerve injury, the healthy sensory cortex on one side of the brain inhibits its deprived counterpart on the other side.
- Weeding the Tares, Sparing the Wheat
Hyaluronan-coated nanoparticles selectively treat CD44-expressing cancer cells, without damaging healthy tissue.
- Pearls of Wisdom for Pulmonary Fibrosis
Chronic inflammation mediated by alveolar epithelial cells through macrophages may contribute to the development of lung fibrosis in Hermansky Pudlak syndrome patients.
