01 June 2011
Vol 3, Issue 85
  • Contents

    • Perspective

    • Research Articles

    • Editors' Choice

      • DPP4 Joins Weight Watchers

        In patients with metabolic syndrome, human visceral fat secretes an adipokine DPP4 that impairs insulin signaling in muscle, potentially contributing to insulin resistance.

      • Old Dogs and New Tricks

        A combination of standard cytotoxic chemotherapies used for other cancers extends overall survival for pancreatic cancer patients.

      • The Changing Brain

        Spinal cord injury can potentially lead to adaptive changes in the sensory and motor cortical areas of the brain.

About The Cover

Cover image expansion

ONLINE COVER Aiming Off Target. A representation of podocytes, cells that wrap around the capillaries in the kidney and help to filter the blood for excretion. These cells can be damaged during focal segmental glomerulosclerosis (FSGS), a complication of kidney transplantation that responds to treatment with the monoclonal antibody rituximab, typically used to treat lymphomas and leukemias. In this issue, Fornoni et al. reveal that rituximab pinpoints kidney podocytes, reversing the damaging effects of FSGS on the cell's actin cytoskeleton. See the accompanying Perspective by Chan, which examines the impact of this discovery on our understanding of the off-target effects of rituximab on this and possibly other proteinuric diseases. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]