Research ArticleAlzheimer’s Disease

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

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Science Translational Medicine  25 May 2011:
Vol. 3, Issue 84, pp. 84ra44
DOI: 10.1126/scitranslmed.3002230

Article Information

vol. 3 no. 84 84ra44

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 4, 2011
  • Accepted for publication May 5, 2011
  • .

Author Information

  1. Y. Joy Yu1,*,
  2. Yin Zhang2,*,
  3. Margaret Kenrick3,
  4. Kwame Hoyte4,
  5. Wilman Luk4,
  6. Yanmei Lu4,
  7. Jasvinder Atwal1,
  8. J. Michael Elliott5,
  9. Saileta Prabhu3,
  10. Ryan J. Watts1, and
  11. Mark S. Dennis2,
  1. 1Neurodegeneration Labs, Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
  2. 2Department of Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA.
  3. 3Department of Developmental Sciences, Genentech Inc., South San Francisco, CA 94080, USA.
  4. 4Department of Assay Automation Technology, Genentech Inc., South San Francisco, CA 94080, USA.
  5. 5Department of Protein Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.
  1. To whom correspondence should be addressed. E-mail: rwatts{at}gene.com (R.J.W.); msd{at}gene.com (M.S.D.)

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