Research ArticleAlzheimer’s Disease

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo

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Science Translational Medicine  25 May 2011:
Vol. 3, Issue 84, pp. 84ra43
DOI: 10.1126/scitranslmed.3002254

Article Information

vol. 3 no. 84 84ra43

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 9, 2011
  • Accepted for publication May 5, 2011
  • .

Author Information

  1. Jasvinder K. Atwal1,
  2. Yongmei Chen2,
  3. Cecilia Chiu2,
  4. Deborah L. Mortensen3,
  5. William J. Meilandt1,
  6. Yichin Liu4,
  7. Christopher E. Heise4,
  8. Kwame Hoyte5,
  9. Wilman Luk5,
  10. Yanmei Lu5,
  11. Kun Peng6,
  12. Ping Wu7,
  13. Lionel Rouge7,
  14. Yingnan Zhang8,
  15. Robert A. Lazarus8,
  16. Kimberly Scearce-Levie1,
  17. Weiru Wang7,
  18. Yan Wu2,
  19. Marc Tessier-Lavigne1 and
  20. Ryan J. Watts1,*
  1. 1Neurodegeneration Labs, Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  2. 2Department of Antibody Engineering, Genentech, South San Francisco, CA 94080, USA.
  3. 3Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech, South San Francisco, CA 94080, USA.
  4. 4Department of Biochemical Pharmacology, Genentech, South San Francisco, CA 94080, USA.
  5. 5Department of Assay and Automation Technology, Genentech, South San Francisco, CA 94080, USA.
  6. 6Department of BioAnalytical Research and Development, Genentech, South San Francisco, CA 94080, USA.
  7. 7Department of Structural Biology, Genentech, South San Francisco, CA 94080, USA.
  8. 8Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA 94080, USA.
  1. *To whom correspondence should be addressed. E-mail: rwatts{at}gene.com

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