Research ArticleGraft-Versus-Host Disease

Massive ex Vivo Expansion of Human Natural Regulatory T Cells (Tregs) with Minimal Loss of in Vivo Functional Activity

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Science Translational Medicine  18 May 2011:
Vol. 3, Issue 83, pp. 83ra41
DOI: 10.1126/scitranslmed.3001809

Article Information

vol. 3 no. 83 83ra41

PubMed: 
Print ISSN: 
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History: 
  • Received for publication October 14, 2010
  • Accepted for publication March 25, 2011

Author Information

  1. Keli L. Hippen1,*,
  2. Sarah C. Merkel1,
  3. Dawn K. Schirm1,
  4. Christine M. Sieben1,
  5. Darin Sumstad2,
  6. Diane M. Kadidlo2,
  7. David H. McKenna2,
  8. Jonathan S. Bromberg3,
  9. Bruce L. Levine4,
  10. James L. Riley4,
  11. Carl H. June4,
  12. Phillip Scheinberg5,
  13. Daniel C. Douek5,
  14. Jeffrey S. Miller6,
  15. John E. Wagner1 and
  16. Bruce R. Blazar1,*
  1. 1Division of Bone Marrow Transplantation, Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA.
  2. 2Molecular and Cellular Therapeutics Facility, University of Minnesota, Minneapolis, MN 55455, USA.
  3. 3Division of Transplantation, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  4. 4Abramson Family Cancer Center Research Institute, University of Pennsylvania Cancer Center, Philadelphia, PA 19104, USA.
  5. 5Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892–3005, USA.
  6. 6Division of Bone Marrow Transplantation, Department of Medicine, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA.
  1. *To whom correspondence should be addressed. E-mail: hippe002{at}umn.edu (K.L.H.); blaza001{at}umn.edu (B.R.B.)

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