18 May 2011
Vol 3, Issue 83

About The Cover

Cover image expansion

ONLINE COVER Handling Rejection. Regulatory T cells (purple) can be stimulated by dendritic cells (blue) to suppress the immune cells (tan) that cause graft-versus-host disease or lead to transplant rejection. Three papers in this week’s Science Translational Medicine discuss new ways to expand regulatory T cells. Sagoo et al. describe a method to sort antigen-specific regulatory T cells based on their activation status; Feng et al. use a FDA-approved drug to generate graft-reactive regulatory cells; and Hippen et al. expand regulatory T cells to sufficient numbers for wide-scale clinical use. See also the accompanying Perspective by Wang et al. on the clinical use of regulatory T cells as personalized therapeutic agents. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]