11 May 2011
Vol 3, Issue 82

About The Cover

Cover image expansion

ONLINE COVER Rescuing Prometheus. The liver is the only human organ with remarkable powers of regeneration, but injury caused by toxins or diseases such as cirrhosis or cancer destroy this ability. Liu et al. now demonstrate the capacity of human hepatic cells (yellow) derived from human induced pluripotent stem cells to regenerate injured liver tissue when transplanted into mice treated with a toxin. They show that after intravenous injection, these human hepatic cells (yellow) not only became engrafted in the damaged liver tissue of the toxin-treated mice but also promoted their survival by producing liver proteins and rescuing liver function. [CREDIT: Y. KIM AND Y Y. JANG, JOHNS HOPKINS SCHOOL OF MEDICINE]