Contents
Vol 3, Issue 82
Contents
Commentary
- Universal Design of Research: Inclusion of Persons with Disabilities in Mainstream Biomedical Studies
Simple changes in clinical study design allow individuals with disabilities to participate in and contribute to research.
Perspective
- Diagnosing the Individual to Control the Epidemic
Infection experiments provide a basis for understanding how epidemics propagate through individuals, emphasizing the importance of diagnostics.
Research Articles
- Losartan Restores Skeletal Muscle Remodeling and Protects Against Disuse Atrophy in Sarcopenia
Losartan improves muscle remodeling and protects against immobilization atrophy by mediating pathways critical for muscle homeostasis.
- Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions
In psoriasis, cytosolic DNA in keratinocytes triggers maturation of the cytokine IL-1β via the AIM2 inflammasome.
- In Vivo Liver Regeneration Potential of Human Induced Pluripotent Stem Cells from Diverse Origins
Hepatic cells derived from human induced pluripotent stem cells of various origins contribute to liver regeneration in vivo.
Editors' Choice
- Targeting Targets for Treatment in Inflammatory Bowel Disease
Finding new ways to interfere with the migration of immune cells into the gut may prove to be a valuable approach for treatment of inflammatory bowel disease.
- At the Crossroads: Tumor Metabolism and Epigenetics
Mutations in isocitrate dehydrogenases and the resulting accumulation of the oncometabolite 2-hydroxyglutarate represent possible targets for cancer therapy.
- Focusing on Attention Deficit
A genetic variant associated with a higher-than-normal incidence of attention deficit hyperactivity disorder can be modeled in mice.
- HIV Gets a Wake-Up Call
Liposomal delivery of a protein that activates latent HIV may help to eradicate reservoirs of the latent virus in resting T cells.
- OutFOXing Tolerance in Multiple Sclerosis
Inflammatory conditions such as autoimmune disease can change the phenotype of Treg cells and impair their function.
Podcast
- Science Translational Medicine Podcast: 11 May 2011
A conversation with Ronald D. Cohn about a new use for the FDA-approved drug losartan to treat sarcopenia.
