27 April 2011
Vol 3, Issue 80

About The Cover

Cover image expansion

ONLINE COVER Mitigating Metabolic Pandemonium. This week in Science Translational Medicine, the spotlight is on mitochondrial metabolic pathways and their prominence in glycemic control and weight loss. In two cohorts of obese patients with type 2 diabetes, Laferrère and colleagues dissect the enhanced decrease in circulating branched-chain amino acids (BCAAs) and their metabolites that manifests after gastric bypass (GBP) relative to dietary intervention. The data support the hypothesis that the surgical intervention promotes enhanced BCAA metabolism by mechanisms separate from weight loss and suggest that changes in circulating amino acids spur the correction of glycemic control observed shortly after GBP. See also the accompanying Perspective by Gerszten and Wang, who discuss these findings in the context of other recent related results. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]