Contents
Vol 3, Issue 79
Contents
Editorial
- Gene Therapy for Parkinson's Disease Shows Promise
A gene therapy trial for Parkinson's disease met its primary endpoint, but challenges remain.
Perspectives
- HIV-1 Vaccines and Adaptive Trial Designs
Development of an HIV vaccine could be accelerated by testing candidate vaccines using adaptive clinical trial designs.
- Biomarkers for Parkinson’s Disease
Identifying much-needed biomarkers for detecting early Parkinson’s disease will accelerate drug development.
Research Article
- The Fate and Toxicity of Raman-Active Silica-Gold Nanoparticles in Mice
Gold-core nanoparticles designed for imaging by Raman spectroscopy in patients are generally nontoxic in mice, causing only temporary liver inflammation when given intravenously.
Reports
- Electronic Medical Records for Genetic Research: Results of the eMERGE Consortium
Clinical data captured in electronic medical records accurately identify cases and controls for genome-wide association studies.
Editors' Choice
- Divide and Conquer: Teasing Out the Cause of Heart Defects in Down Syndrome
Individual genetic mutations may contribute to the distinct conditions that make up Down syndrome.
- Fishing for Answers
A zebrafish model of tuberculosis reveals new insights into how drug tolerance emerges in mycobacteria.
- The Power of Epistasis
Mutations in human immunodeficiency virus genes work together to heighten drug resistance.
- Actionable Pharmacogenetics for Epilepsy
An HLA allele is a major genetic risk factor for a severe adverse reaction to an anti-epileptic drug in Europeans.
- Breast Cancer Imaging Goes Green
Near-infrared imaging of the breasts after intravenous injection of indocyanine green distinguishes benign from malignant lesions.
