Contents
Vol 3, Issue 78
Contents
Commentary
- One Foundation’s Strategy to Accelerate Drug Discovery Through Genomics
The founder of the Multiple Myeloma Research Foundation discusses ways to accelerate drug discovery for a rare disease.
Perspective
- Community Health Care: Therapeutic Opportunities in the Human Microbiome
The human microbiome harbors tremendous untapped therapeutic potential.
Research Articles
- IL-25 Causes Apoptosis of IL-25R–Expressing Breast Cancer Cells Without Toxicity to Nonmalignant Cells
Normal mammary epithelial cells secrete an anticancer cytokine, IL-25, suggesting that IL-25 receptor signaling may be a therapeutic target for breast cancer.
- Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model
Bacterial clearance in macrophages from lungs with chronic obstructive pulmonary disease is improved by stimulating the Nrf2 antioxidant signaling pathway.
Editors' Choice
- Hunting for Those with Heavy Hearts
Biomarkers may help to identify people with heart hypertrophy before the manifestation of heart failure.
- Shocking Memories After Surgery
Overexpression of heat shock protein can prevent postoperative memory impairment in mice.
- Nanoparticles and Jelly
An implantable cisplatin-nanoparticle–hydrogel system shows promise for inhibiting tumor growth in vivo.
- A Little Tolerance Can Prevent a Broken Heart
Lack of thymic tolerance to α-MyHC may contribute to myocarditis development in patients with autoimmune-mediated myocardial disease.
