06 April 2011
Vol 3, Issue 77
  • Contents

    • Perspective

    • Research Articles

      • Genital HIV-1 RNA Predicts Risk of Heterosexual HIV-1 Transmission

        Genital HIV-1 RNA quantity predicts risk of heterosexual HIV-1 transmission independently of plasma HIV-1 concentration.

      • CD44-SLC1A2 Gene Fusions in Gastric Cancer

        One partner of a fusion gene found in gastric cancer, CD44-SLC1A2, may contribute to the tumor’s abnormal metabolism.

    • State of the Art Review

      • Alzheimer’s Disease: The Challenge of the Second Century

        In the first of our State of the Art Review series, David M. Holtzman, John C. Morris, and Alison M. Goate explore the rapid pace of Alzheimer’s disease research and the challenges to translating research breakthroughs into clinical treatments.

    • Editors' Choice

      • Starve Now, Gain Later

        Specific, durable epigenetic changes induced in the fetus by maternal diet may spur development of type 2 diabetes in adulthood.

      • Patient, Heal Thyself

        CD40 activation boosts the antitumor response of stromal-associated macrophages in humans and mice with pancreatic cancer.

      • Enemies Among Us

        Invasive streptococcal strains are genetically similar to pharyngitis strains, yet polymorphisms lead to changes in invasive potential.

      • Communicating Wirelessly with Our Bodies

        Wireless communication for biomedical devices is enabled by using the human body for signal transmission.

    • Podcast

About The Cover

Cover image expansion

ONLINE COVER Unraveling the Tangled Web of Alzheimer's Disease. There is no drug that can delay the onset or slow the insidious course of Alzheimer's disease, a devastating neurodegenerative disorder that affects 30 million people worldwide. As Holtzman et al. discuss in their State of the Art Review, advances in understanding the aberrant molecular events in neurons that contribute to their demise are yielding new molecular targets for drug development. Depicted are two pathological hallmarks of Alzheimer's disease: neurofibrillary tangles (turquoise) inside the neuron that are composed of aberrantly phosphorylated tau protein, and aggregates of the neurotoxic β-amyloid peptide (pink) next to the neuron. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]