Contents

Contents

• Perspective

  • HIV Transmission: Time for Translational Studies to Bridge the Gap

    By Peter Anton, Betsy C. Herold

    Science Translational Medicine06 Apr 2011 : 77ps11 Full AccessRestricted Access

    A large clinical trial reveals that HIV-1 RNA loads predict the risk of heterosexual transmission and identifies new directions for translational research.

    • Abstract
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• Research Articles

  • Genital HIV-1 RNA Predicts Risk of Heterosexual HIV-1 Transmission

    By Jared M. Baeten, Erin Kahle, Jairam R. Lingappa, Robert W. Coombs, Sinead Delany-Moretlwe, Edith Nakku-Joloba, Nelly R. Mugo, Anna Wald, Lawrence Corey, Deborah Donnell, Mary S. Campbell, James I. Mullins, Connie Celum

    Science Translational Medicine06 Apr 2011 : 77ra29 Full AccessRestricted Access

    Genital HIV-1 RNA quantity predicts risk of heterosexual HIV-1 transmission independently of plasma HIV-1 concentration.

    • Editor's Summary
    • Abstract
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  • CD44-SLC1A2 Gene Fusions in Gastric Cancer

    By Jiong Tao, Nian Tao Deng, Kalpana Ramnarayanan, Baohua Huang, Hue Kian Oh, Siew Hong Leong, Seong Soo Lim, Iain Beehuat Tan, Chia Huey Ooi, Jeanie Wu, Minghui Lee, Shenli Zhang, Sun Young Rha, Hyun Cheol Chung, Duane T. Smoot, Hassan Ashktorab, Oi Lian Kon, Valere Cacheux, Celestial Yap, Nallasivam Palanisamy, Patrick Tan

    Science Translational Medicine06 Apr 2011 : 77ra30 Full AccessRestricted Access

    One partner of a fusion gene found in gastric cancer, CD44-SLC1A2, may contribute to the tumor’s abnormal metabolism.

    • Editor's Summary
    • Abstract
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• State of the Art Review

  • Alzheimer’s Disease: The Challenge of the Second Century

    By David M. Holtzman, John C. Morris, Alison M. Goate

    Science Translational Medicine06 Apr 2011 : 77sr1 Full AccessRestricted Access

    In the first of our State of the Art Review series, David M. Holtzman, John C. Morris, and Alison M. Goate explore the rapid pace of Alzheimer’s disease research and the challenges to translating research breakthroughs into clinical treatments.

    • Abstract
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• Editors' Choice

  • Starve Now, Gain Later

    By Mickie H. Cheng

    Science Translational Medicine06 Apr 2011 : 77ec46 Full AccessRestricted Access

    Specific, durable epigenetic changes induced in the fetus by maternal diet may spur development of type 2 diabetes in adulthood.

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  • Patient, Heal Thyself

    By David S. Hong

    Science Translational Medicine06 Apr 2011 : 77ec47 Full AccessRestricted Access

    CD40 activation boosts the antitumor response of stromal-associated macrophages in humans and mice with pancreatic cancer.

    • Full Text

  • Enemies Among Us

    By Melissa Nyendak

    Science Translational Medicine06 Apr 2011 : 77ec48 Full AccessRestricted Access

    Invasive streptococcal strains are genetically similar to pharyngitis strains, yet polymorphisms lead to changes in invasive potential.

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  • Communicating Wirelessly with Our Bodies

    By Wei Wang

    Science Translational Medicine06 Apr 2011 : 77ec49 Full AccessRestricted Access

    Wireless communication for biomedical devices is enabled by using the human body for signal transmission.

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• Podcast

  • Science Translational Medicine Podcast: 6 April 2011

    By David M. Holtzman, Orla Smith

    Science Translational Medicine06 Apr 2011 : 77pc5 Full AccessRestricted Access

    A conversation with David M. Holtzman about the challenges of developing new treatments for Alzheimer's disease.

    • Abstract