Contents
Vol 3, Issue 77
Contents
Perspective
- HIV Transmission: Time for Translational Studies to Bridge the Gap
A large clinical trial reveals that HIV-1 RNA loads predict the risk of heterosexual transmission and identifies new directions for translational research.
Research Articles
- Genital HIV-1 RNA Predicts Risk of Heterosexual HIV-1 Transmission
Genital HIV-1 RNA quantity predicts risk of heterosexual HIV-1 transmission independently of plasma HIV-1 concentration.
- CD44-SLC1A2 Gene Fusions in Gastric Cancer
One partner of a fusion gene found in gastric cancer, CD44-SLC1A2, may contribute to the tumor’s abnormal metabolism.
State of the Art Review
- Alzheimer’s Disease: The Challenge of the Second Century
In the first of our State of the Art Review series, David M. Holtzman, John C. Morris, and Alison M. Goate explore the rapid pace of Alzheimer’s disease research and the challenges to translating research breakthroughs into clinical treatments.
Editors' Choice
- Starve Now, Gain Later
Specific, durable epigenetic changes induced in the fetus by maternal diet may spur development of type 2 diabetes in adulthood.
- Patient, Heal Thyself
CD40 activation boosts the antitumor response of stromal-associated macrophages in humans and mice with pancreatic cancer.
- Enemies Among Us
Invasive streptococcal strains are genetically similar to pharyngitis strains, yet polymorphisms lead to changes in invasive potential.
- Communicating Wirelessly with Our Bodies
Wireless communication for biomedical devices is enabled by using the human body for signal transmission.
Podcast
- Science Translational Medicine Podcast: 6 April 2011
A conversation with David M. Holtzman about the challenges of developing new treatments for Alzheimer's disease.