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Use of Mutant-Specific Ion Channel Characteristics for Risk Stratification of Long QT Syndrome Patients

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Science Translational Medicine  30 Mar 2011:
Vol. 3, Issue 76, pp. 76ra28
DOI: 10.1126/scitranslmed.3001551

Article Information

vol. 3 no. 76 76ra28

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 2, 2010
  • Accepted for publication March 11, 2011
  • .

Author Information

  1. Christian Jons1,*,
  2. Jin O-Uchi2,*,
  3. Arthur J. Moss1,
  4. Matthias Reumann3,
  5. John J. Rice3,
  6. Ilan Goldenberg3,
  7. Wojciech Zareba1,
  8. Arthur A. M. Wilde4,
  9. Wataru Shimizu5,
  10. Jorgen K. Kanters6,7,
  11. Scott McNitt1,
  12. Nynke Hofman8,
  13. Jennifer L. Robinson1 and
  14. Coeli M. B. Lopes2,
  1. 1Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
  2. 2Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
  3. 3Functional Genomics and Systems Biology Group, IBM Thomas J. Watson Research Center, Yorktown Heights, NY 10598, USA.
  4. 4Heart Failure Research Centre, Department of Cardiology, Academic Medical Centre, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.
  5. 5National Cardiovascular Center, Suita 565-8565, Japan.
  6. 6Gentofte University Hospital, DK 2820 Copenhagen, Denmark.
  7. 7Danish National Research Foundation Center for Cardiac Arrhythmias, DK 2200 Copenhagen, Denmark.
  8. 8Department of Clinical Genetics, Academic Medical Centre, University of Amsterdam, 1105 AZ, Amsterdam, Netherlands.
  1. To whom correspondence should be addressed. E-mail: coeli_lopes{at}urmc.rochester.edu

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