30 March 2011
Vol 3, Issue 76

About The Cover

Cover image expansion

ONLINE COVER Your Beating Heart. The human heart beats over a billion times in a lifetime, sustained by the rhythmic opening and closing of ion channels, as represented here by an electrocardiogram (ECG) in green. Mutations in these channels can cause arrhythmic heart beats, which sometimes result in sudden death. Only some of these at-risk patients can be identified beforehand by abnormalities in the ECG. For the remaining patients, Jons et al. find that the rate at which a potassium channel opens can accurately predict who is at risk for lethal arrhythmias, opening the door for preventive therapy. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]