Contents
Vol 3, Issue 76
Contents
Commentary
- The Precompetitive Space: Time to Move the Yardsticks
A recent meeting of minds set into motion an open-access initiative designed to achieve proof of clinical mechanism for selected disease targets.
Perspective
- Human Pluripotent Stem Cells: Decoding the Naïve State
Human stem cells exist in functionally distinct states that must be deciphered before these versatile reagents can be used to transform medicine.
Research Articles
- A MEK Inhibitor Abrogates Myeloproliferative Disease in Kras Mutant Mice
Inhibiting the Raf/MEK/ERK pathway reverses the harmful effects of oncogenic Kras on hematopoietic differentiation, suggesting a strategy for treating myeloproliferative neoplasms.
- Use of Mutant-Specific Ion Channel Characteristics for Risk Stratification of Long QT Syndrome Patients
Mutations that slow the opening of potassium channels in the heart can predict risk for long QT syndrome, a heart arrhythmia that can cause sudden death.
Editors' Choice
- When the Heart Forgets to Beat
Whole-genome sequencing combined with a genome-wide association study yields important genetic predictors of sinus node dysfunction.
- Fetal DNA: A Needle in the Haystack
A fetal epigenetic footprint in mothers’ blood paves the way for noninvasively diagnosing Down’s syndrome.
- Molecular Cancer Screening Comes Alive
Epigenetic signatures help to predict risk of bladder cancer.
- PEG Gets to the Heart of the Matter
Polyethylene glycol improves cardiac function by inhibiting the apoptotic pathway induced by ischemia-reperfusion injury.