Contents

Contents

• Commentary

  • The Precompetitive Space: Time to Move the Yardsticks

    By Thea Norman, Aled Edwards, Chas Bountra, Stephen Friend

    Science Translational Medicine30 Mar 2011 : 76cm10 Full AccessRestricted Access

    A recent meeting of minds set into motion an open-access initiative designed to achieve proof of clinical mechanism for selected disease targets.

    • Abstract
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• Perspective

  • Human Pluripotent Stem Cells: Decoding the Naïve State

    By Wenlin Li, Sheng Ding

    Science Translational Medicine30 Mar 2011 : 76ps10 Full AccessRestricted Access

    Human stem cells exist in functionally distinct states that must be deciphered before these versatile reagents can be used to transform medicine.

    • Abstract
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• Research Articles

  • A MEK Inhibitor Abrogates Myeloproliferative Disease in Kras Mutant Mice

    By Natalya Lyubynska, Matthew F. Gorman, Jennifer O. Lauchle, Wan Xing Hong, Jon K. Akutagawa, Kevin Shannon, Benjamin S. Braun

    Science Translational Medicine30 Mar 2011 : 76ra27 Full AccessRestricted Access

    Inhibiting the Raf/MEK/ERK pathway reverses the harmful effects of oncogenic Kras on hematopoietic differentiation, suggesting a strategy for treating myeloproliferative neoplasms.

    • Editor's Summary
    • Abstract
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  • Use of Mutant-Specific Ion Channel Characteristics for Risk Stratification of Long QT Syndrome Patients

    By Christian Jons, Jin O-Uchi, Arthur J. Moss, Matthias Reumann, John J. Rice, Ilan Goldenberg, Wojciech Zareba, Arthur A. M. Wilde, Wataru Shimizu, Jorgen K. Kanters, Scott McNitt, Nynke Hofman, Jennifer L. Robinson, Coeli M. B. Lopes

    Science Translational Medicine30 Mar 2011 : 76ra28 Full AccessRestricted Access

    Mutations that slow the opening of potassium channels in the heart can predict risk for long QT syndrome, a heart arrhythmia that can cause sudden death.

    • Editor's Summary
    • Abstract
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• Editors' Choice

  • When the Heart Forgets to Beat

    By Samir Damani

    Science Translational Medicine30 Mar 2011 : 76ec42 Full AccessRestricted Access

    Whole-genome sequencing combined with a genome-wide association study yields important genetic predictors of sinus node dysfunction.

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  • Fetal DNA: A Needle in the Haystack

    By Carmella Evans-Molina

    Science Translational Medicine30 Mar 2011 : 76ec43 Full AccessRestricted Access

    A fetal epigenetic footprint in mothers’ blood paves the way for noninvasively diagnosing Down’s syndrome.

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  • Molecular Cancer Screening Comes Alive

    By Richard J. Lin

    Science Translational Medicine30 Mar 2011 : 76ec44 Full AccessRestricted Access

    Epigenetic signatures help to predict risk of bladder cancer.

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  • PEG Gets to the Heart of the Matter

    By Christopher L. Skelly

    Science Translational Medicine30 Mar 2011 : 76ec45 Full AccessRestricted Access

    Polyethylene glycol improves cardiac function by inhibiting the apoptotic pathway induced by ischemia-reperfusion injury.

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