Research ArticleCancer
Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors
- Lecia V. Sequist1,2,*†,
- Belinda A. Waltman2,*,
- Dora Dias-Santagata2,3,*,
- Subba Digumarthy2,4,
- Alexa B. Turke1,2,
- Panos Fidias1,2,
- Kristin Bergethon3,
- Alice T. Shaw1,2,
- Scott Gettinger5,
- Arjola K. Cosper1,
- Sara Akhavanfard2,3,
- Rebecca S. Heist1,2,
- Jennifer Temel1,2,
- James G. Christensen6,
- John C. Wain1,2,7,
- Thomas J. Lynch5,
- Kathy Vernovsky1,
- Eugene J. Mark2,3,
- Michael Lanuti1,2,7,
- A. John Iafrate2,3,
- Mari Mino-Kenudson2,3 and
- Jeffrey A. Engelman1,2,†
- 1Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
- 2Harvard Medical School, Boston, MA 02115, USA.
- 3Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
- 4Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
- 5Yale University School of Medicine and Yale Cancer Center, New Haven, CT 06520, USA.
- 6Translational Pharmacology, Pfizer Oncology, La Jolla, CA 92121, USA.
- 7Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
- †↵To whom correspondence should be addressed. E-mail: lvsequist{at}partners.org (L.V.S.); jengelman{at}partners.org (J.A.E.)
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Science Translational Medicine 23 Mar 2011:
Vol. 3, Issue 75, pp. 75ra26
DOI: 10.1126/scitranslmed.3002003
Vol. 3, Issue 75, pp. 75ra26
DOI: 10.1126/scitranslmed.3002003
Lecia V. Sequist
Belinda A. Waltman
Dora Dias-Santagata
Subba Digumarthy
Alexa B. Turke
Panos Fidias
Kristin Bergethon
Alice T. Shaw
Scott Gettinger
Arjola K. Cosper
Sara Akhavanfard
Rebecca S. Heist
Jennifer Temel
James G. Christensen
John C. Wain
Thomas J. Lynch
Kathy Vernovsky
Eugene J. Mark
Michael Lanuti
A. John Iafrate
Mari Mino-Kenudson
Jeffrey A. Engelman
