Research ArticleCancer

Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

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Science Translational Medicine  23 Mar 2011:
Vol. 3, Issue 75, pp. 75ra26
DOI: 10.1126/scitranslmed.3002003

Article Information

vol. 3 no. 75 75ra26

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 6, 2010
  • Accepted for publication March 4, 2011
  • .

Author Information

  1. Lecia V. Sequist1,2,*,
  2. Belinda A. Waltman2,*,
  3. Dora Dias-Santagata2,3,*,
  4. Subba Digumarthy2,4,
  5. Alexa B. Turke1,2,
  6. Panos Fidias1,2,
  7. Kristin Bergethon3,
  8. Alice T. Shaw1,2,
  9. Scott Gettinger5,
  10. Arjola K. Cosper1,
  11. Sara Akhavanfard2,3,
  12. Rebecca S. Heist1,2,
  13. Jennifer Temel1,2,
  14. James G. Christensen6,
  15. John C. Wain1,2,7,
  16. Thomas J. Lynch5,
  17. Kathy Vernovsky1,
  18. Eugene J. Mark2,3,
  19. Michael Lanuti1,2,7,
  20. A. John Iafrate2,3,
  21. Mari Mino-Kenudson2,3 and
  22. Jeffrey A. Engelman1,2,
  1. 1Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
  2. 2Harvard Medical School, Boston, MA 02115, USA.
  3. 3Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
  4. 4Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
  5. 5Yale University School of Medicine and Yale Cancer Center, New Haven, CT 06520, USA.
  6. 6Translational Pharmacology, Pfizer Oncology, La Jolla, CA 92121, USA.
  7. 7Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
  1. To whom correspondence should be addressed. E-mail: lvsequist{at}partners.org (L.V.S.); jengelman{at}partners.org (J.A.E.)

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