CommentaryClinical Trials

Accrual to Cancer Clinical Trials in the Era of Molecular Medicine

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Science Translational Medicine  23 Mar 2011:
Vol. 3, Issue 75, pp. 75cm9
DOI: 10.1126/scitranslmed.3001712

Figures

  • Fig. 1. Patient empowerment.

    Patient advocate groups help individuals to play an active role in finding clinical trials for which they are eligible. For example, the aim of the Love/Avon Army of Women initiative is to recruit 1 million women—breast cancer survivors and women at risk for breast cancer—to participate in breast cancer–related studies.

    CREDIT: JEFFREY HAMILTON

Tables

  • Table 1.

    Barriers to enrollment in clinical trials.

    • Insufficient physician time/interest
    • Lack of dedicated research staff
    • Lack of equipoise in clinical trial design
    • Increasing protocol eligibility requirements and protocol complexity
    • Lack of reimbursement for physician management of patients in trials
    • Off-label prescribing of drugs
    • Lack of insurance coverage for patients participating in clinical trials
    • Regulatory liability and burden
    • Insufficient patient awareness/demand

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