23 March 2011
Vol 3, Issue 75
  • Contents

    • Commentaries

    • Research Articles

      • Breast Cancer Methylomes Establish an Epigenomic Foundation for Metastasis

        Breast cancer methylomes contribute to metastatic potential, modulate the metastasis transcriptome, and predict disease outcome.

      • Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

        Lung cancers undergo dynamic genetic and histological changes upon developing resistance to EGFR inhibitors.

    • Editors' Choice

      • Two Peas in a Pod

        Eclampsia and preeclampsia may be branches off a common event that takes place at the utero-placenta junction.

      • Genetic Tug of War in the Immune System

        A genome-wide association study uncovers loci that confer risk for an immune-mediated kidney disease.

      • The Hunt for Red October

        Investigators have improved medical sonar (ultrasound) to hunt down and track elusive cancer cells.

    • Podcast

About The Cover

Cover image expansion

ONLINE COVER myPad. Modern technologies in genomics, biomarker detection, and molecular imaging can provide intricate medical information about an individual cancer patient that enables physicians to select an appropriate treatment regimen. In this issue of Science Translational Medicine, Mendelsohn argues in his Commentary that the U.S. National Cancer Institute–sponsored collaborative clinical trials program needs an overhaul in its operations and an infusion of adequate funding. See also the accompanying Commentary by Schilsky on patient accrual for cancer clinical trials. [CREDIT: CHRIS BICKEL/SCIENCE TRANSLATIONAL MEDICINE]