Contents
Vol 3, Issue 75
Contents
Commentaries
- A National Cancer Clinical Trials System for Targeted Therapies
Clinical cancer research requires a well-supported and efficient national clinical trials network that engages in innovative trials of modern cancer therapies.
- Accrual to Cancer Clinical Trials in the Era of Molecular Medicine
In the testing of targeted cancer therapies, new issues can complicate the decision by patients or providers to participate in clinical trials.
Research Articles
- Breast Cancer Methylomes Establish an Epigenomic Foundation for Metastasis
Breast cancer methylomes contribute to metastatic potential, modulate the metastasis transcriptome, and predict disease outcome.
- Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors
Lung cancers undergo dynamic genetic and histological changes upon developing resistance to EGFR inhibitors.
Editors' Choice
- Two Peas in a Pod
Eclampsia and preeclampsia may be branches off a common event that takes place at the utero-placenta junction.
- Strike Three: Positive Progress on the Triple Negative
Triple-negative breast cancers are driven by—surprise!—a tumor suppressor that regulates protein tyrosine kinases.
- Genetic Tug of War in the Immune System
A genome-wide association study uncovers loci that confer risk for an immune-mediated kidney disease.
- The Hunt for Red October
Investigators have improved medical sonar (ultrasound) to hunt down and track elusive cancer cells.
Podcast
- Science Translational Medicine Podcast: 23 March 2011
A conversation with Timothy Chan about a new way to predict breast cancer metastasis.