Research ArticleCystic Fibrosis

The ΔF508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis–Like Disease in Pigs

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Science Translational Medicine  16 Mar 2011:
Vol. 3, Issue 74, pp. 74ra24
DOI: 10.1126/scitranslmed.3001868

Article Information

vol. 3 no. 74 74ra24

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 28, 2010
  • Accepted for publication February 18, 2011
  • .

Author Information

  1. Lynda S. Ostedgaard1,*,
  2. David K. Meyerholz2,*,
  3. Jeng-Haur Chen1,3,*,
  4. Alejandro A. Pezzulo1,
  5. Philip H. Karp1,3,
  6. Tatiana Rokhlina1,
  7. Sarah E. Ernst1,
  8. Robert A. Hanfland4,
  9. Leah R. Reznikov1,
  10. Paula S. Ludwig1,
  11. Mark P. Rogan1,
  12. Greg J. Davis1,
  13. Cassie L. Dohrn2,
  14. Christine Wohlford-Lenane5,
  15. Peter J. Taft1,
  16. Michael V. Rector1,
  17. Emma Hornick1,
  18. Boulos S. Nassar1,
  19. Melissa Samuel6,
  20. Yuping Zhang1,
  21. Sandra S. Richter2,
  22. Aliye Uc5,
  23. Joel Shilyansky4,
  24. Randall S. Prather6,
  25. Paul B. McCray Jr.5,
  26. Joseph Zabner1,
  27. Michael J. Welsh1,3, and
  28. David A. Stoltz1,
  1. 1Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
  2. 2Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
  3. 3Howard Hughes Medical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
  4. 4Department of Surgery, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
  5. 5Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
  6. 6Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA.
  1. To whom correspondence should be addressed. E-mail: michael-welsh{at}uiowa.edu (M.J.W.); david-stoltz{at}uiowa.edu (D.A.S.)

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