16 March 2011
Vol 3, Issue 74
  • Contents

    • Commentary

    • Research Articles

      • CD40 Pathway Activation Status Predicts Response to CD40 Therapy in Diffuse Large B Cell Lymphoma

        A 15-gene expression signature predicts whether a patient with diffuse large B cell lymphoma will respond to dacetuzumab, a therapeutic antibody.

      • β-Arrestin Deficiency Protects Against Pulmonary Fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix

        The signaling molecule β-arrestin is required for the fibroblast invasion of extracellular matrix and thus for the development of pulmonary fibrosis.

      • The ΔF508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis–Like Disease in Pigs

        A common mutation in human cystic fibrosis, CFTR-ΔF508, results in misprocessed CFTR and a cystic fibrosis–like clinical phenotype in pigs.

    • Editors' Choice

      • The Food for Mood

        A diet deficient in omega-3 fatty acids disrupts the endocannabinoid system in the brain and can be linked to psychiatric disease.

      • Cleaning Up the Clutter

        Nanocarriers targeting the delivery of enzyme replacement therapy to endothelial cells are expected to improve therapy for Fabry disease.

About The Cover

Cover image expansion

ONLINE COVER Research to Take Your Breath Away. Shown is an airway lumen from a pig with the most common cystic fibrosis–associated mutation in human patients, ΔF508. The airway is partially blocked with mucus and debris, resulting in the collapse of the nearby lung tissue. Cystic fibrosis is difficult to study in human patients, and mouse models do not accurately reflect human disease. Ostedgaard et al. generated a pig model of cystic fibrosis that carries the ΔF508 mutation and mimics human disease. They hope to use this model to learn about what drives pathology in cystic fibrosis, leading to novel therapies. [CREDIT: D. K. MEYERHOLZ]