Contents

Contents

• Perspective

  • Humanizing Animal Models: A Key to Autoimmune Diabetes Treatment

    By Damien Bresson, Matthias von Herrath

    Science Translational Medicine02 Feb 2011 : 68ps4 Full AccessRestricted Access

    A new humanized mouse model can be used to predict the clinical behavior of therapeutic antibodies for the treatment of Type 1 diabetes.

    • Abstract
    • Full Text
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• Research Articles

  • Readily Available Tissue-Engineered Vascular Grafts

    By Shannon L. M. Dahl, Alan P. Kypson, Jeffrey H. Lawson, Juliana L. Blum, Justin T. Strader, Yuling Li, Roberto J. Manson, William E. Tente, Louis DiBernardo, M. Taylor Hensley, Riley Carter, Tiare P. Williams, Heather L. Prichard, Margaret S. Dey, Keith G. Begelman, Laura E. Niklason

    Science Translational Medicine02 Feb 2011 : 68ra9 Full AccessRestricted Access

    Nonimmunogenic, tissue-engineered vascular grafts stored long-term maintain their patency, strength, and function after transplant in large-animal models.

    • Editor's Summary
    • Abstract
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  • Human CD3 Transgenic Mice: Preclinical Testing of Antibodies Promoting Immune Tolerance

    By Chantal Kuhn, Sylvaine You, Fabrice Valette, Geoff Hale, Peter van Endert, Jean-François Bach, Herman Waldmann, Lucienne Chatenoud

    Science Translational Medicine02 Feb 2011 : 68ra10 Full AccessRestricted Access

    Human CD3 transgenic mice offer a unique preclinical tool to test drugs promoting immune tolerance.

    • Editor's Summary
    • Abstract
    • Full Text
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• Editors' Choice

  • Estrogen and Energy Balance

    By Andrew A. Bremer

    Science Translational Medicine02 Feb 2011 : 68ec13 Full AccessRestricted Access

    Nonclassical estrogen signaling mediates estrogen’s effect on metabolism.

    • Full Text

  • Adiponectin Battles Ceramides

    By Christoph Buettner

    Science Translational Medicine02 Feb 2011 : 68ec14 Full AccessRestricted Access

    The beneficial effects of adiponectin are mediated through the ceramidase activity of its receptor.

    • Full Text

  • Going With the Flow

    By Kenneth W. Ng

    Science Translational Medicine02 Feb 2011 : 68ec15 Full AccessRestricted Access

    Prolonged growth factor delivery using a hydrogel improves blood vessel formation in the heart.

    • Full Text

• Podcast

  • Science Translational Medicine Podcast: 2 February 2011

    By Shannon Dahl, Orla Smith

    Science Translational Medicine02 Feb 2011 : 68pc2 Full AccessRestricted Access

    A conversation with Shannon Dahl about how to bioengineer off-the-shelf vascular grafts for use in surgical transplantation.

    • Abstract