26 January 2011
Vol 3, Issue 67

About The Cover

Cover image expansion

ONLINE COVER A Cancer Bull's-Eye. The image shows the accumulation of porphyrin (red) in head and neck cancer cells (nucleus, blue; mitochondria, green) after down-regulation of a key heme biosynthetic enzyme. This enzyme, uroporphyrinogen decarboxylase (UROD), is essential for the breakdown of a certain type of porphyrinogen, which otherwise builds up and increases cellular oxidative stress. Ito et al. now show that down-regulation of UROD in human head and neck cancer cells is actually beneficial, sensitizing these cells to both radio- and chemotherapy. [CREDIT: E. Ito and E. Moriyama/Ontario Cancer Institute, University Health Network]