Contents

Contents

• Commentary

  • Between Confidentiality and Scientific Exchange: The Place of Publication in Drug Discovery and Pharmaceutical Research

    By Martine Clozel

    Science Translational Medicine26 Jan 2011 : 67cm2 Full AccessRestricted Access

    A combined preclinical and clinical publication might be the ideal approach in translational medicine.

    • Abstract
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• Research Articles

  • Uroporphyrinogen Decarboxylase Is a Radiosensitizing Target for Head and Neck Cancer

    By Emma Ito, Shijun Yue, Eduardo H. Moriyama, Angela B. Hui, Inki Kim, Wei Shi, Nehad M. Alajez, Nirmal Bhogal, GuoHua Li, Alessandro Datti, Aaron D. Schimmer, Brian C. Wilson, Peter P. Liu, Daniel Durocher, Benjamin G. Neel, Brian O’Sullivan, Bernard Cummings, Rob Bristow, Jeff Wrana, Fei-Fei Liu

    Science Translational Medicine26 Jan 2011 : 67ra7 Full AccessRestricted Access

    Uroporphyrinogen decarboxylase inhibition sensitizes head and neck cancer to both radiotherapy and chemotherapy.

    • Editor's Summary
    • Abstract
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  • Manipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host Disease

    By Erin Gatza, Daniel R. Wahl, Anthony W. Opipari, Thomas B. Sundberg, Pavan Reddy, Chen Liu, Gary D. Glick, James L. M. Ferrara

    Science Translational Medicine26 Jan 2011 : 67ra8 Full AccessRestricted Access

    Bioenergetic properties differentiate alloreactive T cells from other proliferating cells and can be exploited to arrest GVHD in mice.

    • Editor's Summary
    • Abstract
    • Full Text
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• Editors' Choice

  • An Epigenetic Road to Genome Instability

    By Joshi Alumkal

    Science Translational Medicine26 Jan 2011 : 67ec10 Full AccessRestricted Access

    The histone methyltransferase EZH2 promotes genomic instability and oncogenic signaling in putative breast cancer stem cells.

    • Full Text

  • Yet Another Reason Rats Don’t Take Day Jobs

    By Rhonda Bentley-Lewis

    Science Translational Medicine26 Jan 2011 : 67ec11 Full AccessRestricted Access

    Feeding rats during the day rather than during their normal night pattern promotes obesity.

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  • Bacterial Breakaway

    By Elaine Cheng

    Science Translational Medicine26 Jan 2011 : 67ec12 Full AccessRestricted Access

    Peptides produced by Staphylococcus epidermidis promote dissemination of this bacterium from biofilms, leading to systemic infection in catheterized patients.

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