Research ArticleAIDS/HIV

An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4+ T Cell Decline in Humanized Mice

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Science Translational Medicine  19 Jan 2011:
Vol. 3, Issue 66, pp. 66ra6
DOI: 10.1126/scitranslmed.3001581

Article Information

vol. 3 no. 66 66ra6

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 10, 2010
  • Accepted for publication December 23, 2010
  • .

Author Information

  1. Charles Preston Neff1,*,
  2. Jiehua Zhou2,*,
  3. Leila Remling1,
  4. Jes Kuruvilla1,
  5. Jane Zhang2,
  6. Haitang Li2,
  7. David D. Smith3,
  8. Piotr Swiderski4,
  9. John J. Rossi2, and
  10. Ramesh Akkina1,
  1. 1Department of Microbiology, Immunology and Pathology, Colorado State University, 1619 Campus Delivery, Fort Collins, CO 80523, USA.
  2. 2Department of Molecular and Cellular Biology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, CA 91010, USA.
  3. 3Division of Biostatistics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
  4. 4Shared Resource-DNA/RNA Peptide, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
  1. To whom correspondence should be addressed. E-mail: akkina{at}colostate.edu (R.A.); jrossi{at}coh.org (J.J.R.)

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